Genes MDPI

Our June Issue has been released! On the cover: "Knockout Mouse Studies Show That Mitochondrial CLPP Peptidase and CLPX Unfoldase Act in Matrix Condensates near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme Production" by Dr. Jana Key, Dr. Suzana Gispert and Prof. Dr. Georg Auburger. Browse the whole issue at: https://lnkd.in/daACCV9u

We're thrilled to announce Dr. Xenia Gonda from Semmelweis University, as the new committee member for Session E. "Human Genomics and Genetic Diseases" at The 2nd International Electronic Conference on Genes (#IECGE2024), held online from December 11-13. Submit your abstract by 8th September: https://lnkd.in/dKgpJ97Y You can also register for free at: https://lnkd.in/dDNGhcRP

Dr. George Chen and colleagues at Yale School of Medicine conducted a systematic review and meta-analysis of the effect of exercise alone on histological endpoints in biopsy-proven non-alcoholic fatty liver disease (#NAFLD): https://lnkd.in/djcn6WEu

Dr. Kenneth Boheler and colleagues at Johns Hopkins Medicine provide an overview of arrhythmogenic cardiomyopathy, summarize findings in other model systems linking desmosome proteins with this disease, and provide a summary of the work in hiPSC-cardiomyocyte models: https://lnkd.in/dKzU_cxF

Prof. Luisa Siculella from Università del Salento et al. reviewed the most used techniques in the field of regenerative medicine, comparing different types of autologous platelet concentrates and their clinical applications to date: https://lnkd.in/dCyvkrj5

‘Gene desert’ is a term given to stretches of DNA within the genome that do not code for proteins. These non-coding regions are still found to be associated with disease. An article published in the open access journal Genes MDPI analyses the potential of a protein called FAM84B, bordering the 8q24.21 gene desert, to cause cancer. The article, cited in BBC News, suggests that FAM84B and the protein Myc may collaborate to increase oncogenic potential. Myc is a gene that is largely upregulated in human cancer and also borders the 8q24.21 gene desert. These results provide leverage for further research on the role of the oncogenic potential of FAM84B and gene deserts such as 8q24.21. Read more about this research: https://brnw.ch/21wL5aF or view the news story: https://brnw.ch/21wL5aE

Review by Dr. Fabiola De Marchi and colleagues at Università degli Studi del Piemonte Orientale overviews the current evidence regarding neuroinflammatory markers in the amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) continuum: https://lnkd.in/dq85Ah-D

Special Issue "Molecular Diagnostic and Prognostic Markers of Human Cancers", edited by Dr. Hilal Arnouk, M.D., Ph.D., has extended its submission deadline until 25 January 2025! Contact ziana.zhang@mdpi.com for APC discounts and more information. https://lnkd.in/dPbeJJj5

Our Most Viewed article in June: "Mitogenomic Insights into the Evolution, Divergence Time, and Ancestral Ranges of 𝘊𝘰𝘵𝘶𝘳𝘯𝘪𝘹 Quails" by Dr. Klaus-Peter Koepfli from Smithsonian-Mason School of Conservation, Dr. Ram Pratap Singh from Central University of South Bihar et al. https://lnkd.in/dAGwFBaf

Dr. Francesca Maria Orlandella and Dr. Peppino Mirabelli are editing an issue which invites articles and reviews that address the peripheral blood miRNA profile to obtain an early tumor detection and exploit their potential as novel therapeutic targets. Submit your paper at: https://lnkd.in/dRMy-X6W